PARP1 Is a TRF2-associated Poly(ADP-Ribose)Polymerase and Protects Eroded Telomeres□D
نویسندگان
چکیده
*Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6445; †Département Intégrité du Génome de l’UMR7175-LC1 du CNRS, Université Louis Pasteur, Ecole Supérieure de Biotechnologie de Strasbourg, 67412 Illkirch Cedex, France; ‡Microscopy Facility, Division of Biology, The University of Tennessee, Knoxville, TN 37996; and §Department of Biochemistry and Cellular and Molecular Biology, The University of Tennessee, Knoxville, TN 37996-0840
منابع مشابه
PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
Poly(ADP-ribose)polymerase 1 (PARP1) is well characterized for its role in base excision repair (BER), where it is activated by and binds to DNA breaks and catalyzes the poly(ADP-ribosyl)ation of several substrates involved in DNA damage repair. Here we demonstrate that PARP1 associates with telomere repeat binding factor 2 (TRF2) and is capable of poly(ADP-ribosyl)ation of TRF2, which affects ...
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تاریخ انتشار 2006